Although there are many joint health products available on the animal health market, it is extremely important to have high-purity ingredients that are readily absorbed, especially in an older companion animal with limited intestinal function. The unique, high-purity ingredients in ThorneVET's Arthroplex meet both criteria. Arthroplex combines the proven joint protective activity of glucosamine sulfate with other cartilage-supportive ingredients, including the botanicals Boswellia and curcumin. Boswellia's efficacy works by inhibiting the activity of lipoxygenase enzymes, thus down-regulating pro-inflammatory reactions in the joints. The curcumin in Arthroplex supports a healthy inflammatory response in the joints, and is the same well-absorbed curcumin phytosome found in CurcuVET®. Bromelain – a protein-digesting enzyme complex from pineapple – stimulates fibrinolytic activity and inhibits thromboxane A2, which helps to down-regulate pro-inflammatory cytokines and prostaglandins.
A recent in vivo study examined a Boswellia extract for its effect on glycosaminoglycan metabolism. Glycosaminoglycans form an important component of connective tissues in a companion animal's body. It was found that the Boswellia extract significantly reduced the degradation of glycosaminoglycans (GAGs) compared to controls.
Evidence indicates that bromelain's action is in part attributable to its ability to inhibit the generation of bradykinin via depletion of the plasma kallikrein system. DL-Phenylalanine, another ingredient of Arthroplex, is a component of the catecholamine neurotransmitter cascade. Supplementation can lead to increased levels of the neurotransmitters norepinephrine and dopamine, which can in turn increase levels of endorphins and enkephalins.
The curcumin in Arthroplex is the same well-absorbed curcumin phytosome found in another ThorneVET product, CurcuVET®. Like Boswellia, curcumin helps support a healthy inflammatory response in the animal's joints.